Goodpasture syndrome involves autoantibodies against basement membranes—affecting the kidneys and which other organ?

Goodpasture syndrome involves autoantibodies against basement membranes—affecting the kidneys and which other organ?

• A. Lungs
• B. Liver
• C. Heart
• D. Spleen

Answer: (A)

Goodpasture syndrome is an autoimmune disease in which antibodies target type IV collagen in basement membranes. These antibodies attack the glomerular basement membrane in the kidneys and the basement membranes of the alveolar capillaries in the lungs. This dual targeting explains why the condition causes both rapidly progressive glomerulonephritis and pulmonary hemorrhage. Other organs like the liver, heart, or spleen don’t share the same vulnerable basement membrane exposure in this condition, so they’re not typically affected. Therefore, the other organ involved is the lungs.

Goodpasture syndrome is an autoimmune disease in which antibodies target type IV collagen in basement membranes. These antibodies attack the glomerular basement membrane in the kidneys and the basement membranes of the alveolar capillaries in the lungs. This dual targeting explains why the condition causes both rapidly progressive glomerulonephritis and pulmonary hemorrhage. Other organs like the liver, heart, or spleen don’t share the same vulnerable basement membrane exposure in this condition, so they’re not typically affected. Therefore, the other organ involved is the lungs.